The effects of β-adrenoceptor blockade on blood pressure at rest In the graph...
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The effects of β-adrenoceptor blockade on blood pressure at rest
In the graph below, data for atenolol and placebo are taken from the collated practical classes in 2022, while data for pindolol was obtained from a previous cohort of students.Figure 4: The effect of β-adrenoceptor antagonists on resting diastolic blood pressure of healthy individuals over time. Placebo (vitamin B6, 10 mg), atenolol (50 mg) or pindolol (10 mg) were administered at 0 min. Data shown as mean ± s.e.m. * p<0.05 drug vs placebo (ANOVA); n = 41-73 per treatment. mmHg, millimetres of mercury.
In your practical class, you learned that β-adrenoceptor blockade should have no effect on blood pressure at rest. What is a possible explanation for the decrease in diastolic blood pressure observed here?
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