In the early stages of T cell activation, after the TCR has engaged with MHC:peptide, which of the following interactions occur?

Question

Accepted Answer

Lck, bound to CD4, leads to phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) on CD3

Answer

Lck binds to CD3 to induce direct signalling through the TCR

Answer

Lck binds to the immunoreceptor tyrosine-based activation motifs (ITAMs) on CD4, and leads to phosphorylation

Answer

Lck binds to the TCR tail and CD4, to link and increase their avidity

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