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A 4-year-old boy has recently returned from a holiday abroad and has now arrived now at the Clinic of Infectious Diseases with his parents due to severe dehydration caused by diarrhoea. The causative bacterium is , which disrupts the structure of one type of intercellular junctions – tight junction = zonula occludens. This physiologically prevents the passage of fluid between cells – the so-called paracellular route. Disruption of these tight junctions results in fluid loss into the lumen of the gastrointestinal tract. Where can we find these tight junctions on cells?
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