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A 4-year-old boy has recently returned from a holiday abroad and has now arrived...

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A 4-year-old boy has recently returned from a holiday abroad and has now arrived now at the Clinic of Infectious Diseases with his parents due to severe

dehydration caused by diarrhoea. The causative bacterium is

Salmonella

,

which disrupts the structure of one type of intercellular junctions – tight

junction = zonula occludens. This physiologically prevents the passage of fluid

between cells – the so-called paracellular route. Disruption of these tight

junctions results in fluid loss into the lumen of the gastrointestinal tract.

Where can we find these tight junctions on cells?

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