Drug Z is actively transported by p-glycoprotein, an efflux
transporter expressed in tissues such as the intestinal epithelium and the
blood–brain barrier, where it limits drug absorption and tissue penetration.

If p-glycoprotein activity is inhibited, which outcome is
MOST LIKELY for Drug Z?

Question

Drug Z is actively transported by p-glycoprotein, an efflux
transporter expressed in tissues such as the intestinal epithelium and the
blood–brain barrier, where it limits drug absorption and tissue penetration.

If p-glycoprotein activity is inhibited, which outcome is
MOST LIKELY for Drug Z?

Accepted Answer

Increased absorption of Drug Z from the gastrointestinal tract

Answer

Decreased entry of Drug Z into the kidneys

Answer

Increased elimination of Drug Z via the kidneys

Answer

Decreased entry of Drug Z into the brain

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Drug Z is actively transported by p-glycoprotein, an efflux transporter express...

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