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A 63-year-old man comes to the physician for a follow-up evaluation of chronic, ...

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A 63-year-old man comes to the physician for

a follow-up evaluation of chronic, retrosternal chest pain. The pain

is worse at night and after heavy meals. He has taken medicines to reduce the

production of stomach acids for several months without any relief from his symptoms.

An upper endoscopy shows changes in the

distal

esophagus

and in the area above the gastro-oesophageal junction. A biopsy

of the distal esophagus shows simple columnar epithelium with goblet

cells, which does not occur normally here. Which type of epithelium should

normally occur here?

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