While the combination therapy Contrave focuses on removing the "brake" on the reward system, the GLP-1 receptor agonist Semaglutide (Ozempic) achieves weight loss by targeting the homeostatic control of food intake through which hypothalamic mechanism?

Question

Accepted Answer

It
provides direct stimulation to anorexigenic POMC neurons while utilising
GABAergic signalling to indirectly inhibit orexigenic NPY/AgRP neurons.

Answer

It acts as a norepinephrine-dopamine reuptake inhibitor to stimulate the reward pathway and address the "Emotional Hunger" phenotype.

Answer

It
serves as an MC4 receptor antagonist to block the β-endorphin-mediated inhibition of the brain's
satiety centres.

Answer

It
triggers a peripheral uncoupling of mitochondrial oxidative phosphorylation,
allowing for energy dissipation as heat without central nervous system
involvement.

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While the combination therapy Contrave focuses on removing the "brake" on the re...

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