When a dendritic cell has captured antigen and migrates to the lymph node, it can present to both CD4 T cells and CD8 T cells. In this situation,

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The TCR specificity of the CD4 and CD8 T cells need to be the same.

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The peptide being presented to both types of T cells is identical.

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The peptides being presented will be governed by the MHC being expressed.

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If CD4 T cell activation is not achieved, then a CD8 T cell response is generated.

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