Cross-presentation by dendritic cells; that can occur in response to virally infected skin cells, is when:

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Dead infected cells are engulfed and viral antigens will be transported into the cytoplasm and enter the MHC class I pathway.

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Viral particles from dead cells bind directly to surface MHC class I and MHC class II molecules to activate T cells.

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The dead infected is held on the surface of the dendritic cell by the MHC class I and MHC class II molecules to present to both CD4 and CD8 T cells

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The dendritic cell engulfs the dead cell and transports antigen from the cytoplasm into the MHC class II pathway so both pathways are utilised.

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