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The researcher suspects that low serum albumin levels in affected patients are n...

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The researcher

suspects that low serum albumin levels in affected patients are not directly

caused by acyl-CoA dehydrogenase defects, but are a secondary consequence of

broader metabolic stress. To explore how acyl-CoA dehydrogenase defects alter

cellular protein expression, the researcher extracts total protein from normal healthy

hepatocytes and a mutant hepatocyte line (HEP-M2).

Which proteomic

technique would you use to compare the protein profiles of the two samples? Explain

why your chosen technique is suitable for this specific application. (2-3

sentences) (2 marks)

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