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Damage like cuts ad burns to tissue causes the release of local chemical mediators which
Ultimately result in desensitization of the TRPM8 channel
Ultimately result in phosphorylation of the TRPV1 channel
Ultimately result in blocking of the TRPV1 channel
Ultimately result in desensitization of the TRPV1 channel
Ultimately result in desensitization of the Na+/K+ ion pump
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