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During B cell development, B cells with BCR that interact strongly with self-ant...

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During B cell development, B cells with BCR that interact strongly with self-antigens can undergo receptor editing. This involves:

The expression of new heavy chains

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The induction of point mutations in the immunoglobulin genes altering the amino acid sequence at the binding site

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The expression of new light chains

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The recombination of completely new heavy and light chains

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