When the AP arrives at the motneuron terminal many vesicles are already fused to the membrane and releasing their ACh molecules even prior to Ca⁺⁺ influx into the terminal with depolarization

The muscle end-plate response, the end plate potential, is very much larger than an EPSP and that gives a large safety factor even with current loss

Vesicles have high [ACh] and can dock quickly, the highly fodled endplate has a high density of Na+ and K+ channels ready to bind ACh, binding of ACh produces a large EPP

Only 10% of the AChR need to open for enough current influx to be able to spread away from the motor end plate and generate a muscle AP

Binding of ACh molecules to the nicotinic receptor lasts much longer than at other receptor-transmitter binding examples.