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During affinity maturation of an antibody, where are the majority of mutations i...

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During affinity maturation of an antibody, where are the majority of mutations in the antibody chains found?

Predominantly in the CDR1 region of the heavy and light chains

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Predominantly in the variable region of the heavy chain

0%

Evenly distributed over the entire length of the heavy and light chains

0%

At the antigen binding sites of the heavy and light chains

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