Which pair correctly matches a historical anti-obesity agent with its specific molecular target and the physiological side effect that led to its clinical failure or withdrawal?

Question

Accepted Answer

Axokine →  Recombinant neurotrophic factor → Loss of efficacy due to neutralising autoantibody formation.

Answer

Lorcaserin → Mitochondrial protonophore uncoupler →Malignant hyperthermia and systemic acidosis.

Answer

Fen-Phen → CB-1 cannabinoid receptor antagonist → Severe major depression and suicidal ideation.

Answer

Rimonabant →Serotonergic 5C receptor agonist → Cardiac valvopathy and pulmonary hypertension.

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Which pair correctly matches a historical anti-obesity agent with its specific m...

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