The article notes phenobarbital as a treatment discussed with the patient. According to the lecture's comparison table, which of the following CORRECTLY describes the response to phenobarbital across all three inherited unconjugated hyperbilirubinemia syndromes?

Question

Answer

Phenobarbital is effective in Crigler-Najjar Type I because the 10–33% residual enzyme activity present in that syndrome can be induced

Answer

Phenobarbital normalizes bilirubin only when the direct bilirubin fraction first exceeds 15% of total bilirubin

Answer

Phenobarbital has no significant effect in any of the three syndromes since all three are genetically determined

Answer

Phenobarbital reduces bilirubin to normal levels equally in all three syndromes with sufficient dosing

Answer

Phenobarbital normalizes bilirubin in Gilbert's syndrome, produces greater than 25% reduction in Crigler-Najjar Type II, and has NO effect in Crigler-Najjar Type I

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The article notes phenobarbital as a treatment discussed with the patient. Accor...

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