There are several reasons self-tolerance mechanisms fail in autoimmunity, including the presence of autoantibodies. Autoantibodies are?

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Produced by plasma cells that are directed against foreign receptors

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Produced by plasma cells that are directed against “self-receptors” and “self-proteins”

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Secreted by all antigen-presenting cells that are directed against our own body's receptors and cells

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Responsible for binding self-antigens, but only with their Fc part

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Produced by basophils that are directed against enemy receptors and cells

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