In a breast cancer cell line with HER2
gene amplification, strong downstream signalling through the MAPK and PI3K
pathways occurs despite low concentrations of extracellular growth factors.
Researchers conclude that in the breast cancer cell line the HER2 receptor
contributes to signalling by facilitating receptor dimerisation independent of
ligand binding.

Which structural property of this
receptor BEST explains this behaviour?

Question

In a breast cancer cell line with HER2
gene amplification, strong downstream signalling through the MAPK and PI3K
pathways occurs despite low concentrations of extracellular growth factors.
Researchers conclude that in the breast cancer cell line the HER2 receptor
contributes to signalling by facilitating receptor dimerisation independent of
ligand binding.

Which structural property of this
receptor BEST explains this behaviour?

Accepted Answer

The HER2 receptor lacks the ability to bind extracellular ligand but readily forms
signalling-competent dimers with other HER family receptors

Answer

The HER2 receptor is
expressed exclusively in tumour cells and therefore bypasses normal regulatory
mechanisms

Answer

The HER2 receptor cannot
participate in receptor dimerisation and signals through an alternative pathway

Answer

The HER2 receptor lacks
intrinsic tyrosine kinase activity and therefore depends on other receptors for
phosphorylation

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In a breast cancer cell line with HER2 gene amplification, strong downstream si...

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