Ca⁺⁺ allows vesicles to qucikly accumulate [ACh] and then dock, the highly fodled endplate has a high density of ACh receptors (AChR), each AChR binds ACh for long, and only 10% of AChR need to be bound to get a large enough EPP

Vesicles have high [ACh] and are predocked, the highly fodled endplate has a high density of ACh estersase  (AChE), each AChE is able to qucikly degrade ACh for recycling, and only 10% of AChR need to be bound to get a large enough EPP

Vesicles have high [ACh] and can dock quickly, the highly fodled endplate has a high density of Na+ and K+ channels ready to bind ACh, binding of ACh produces a large EPP

Vesicles have high [ACh] and are predocked, the highly fodled endplate has a high density of ACh receptors (AChR), each AChR binds ACh for long, and only 10% of AChR need to be bound to get a large enough EPP

Vesicles have high [ACh] and are predocked, the highly fodled endplate has a high density of ACh estersase  (AChE), each AChE is able to qucikly degrade ACh for recycling, and Clathrin can quickly recycle ACh vesicles