Biopsies from inflamed tissues in patients with an
autoimmune disorder reveal large numbers of infiltrating CD4⁺ helper T cells
and CD8⁺ cytotoxic T cells. These cells produce pro-inflammatory cytokines such
as IFN-γ and TNF and are observed in close proximity to damaged host cells
expressing self-antigens. Further analysis shows no evidence of ongoing
infection within the affected tissue.

Which explanation BEST accounts for the
contribution of these T cells to disease progression?

Question

Biopsies from inflamed tissues in patients with an
autoimmune disorder reveal large numbers of infiltrating CD4⁺ helper T cells
and CD8⁺ cytotoxic T cells. These cells produce pro-inflammatory cytokines such
as IFN-γ and TNF and are observed in close proximity to damaged host cells
expressing self-antigens. Further analysis shows no evidence of ongoing
infection within the affected tissue.

Which explanation BEST accounts for the
contribution of these T cells to disease progression?

Answer

Activated
T cells differentiate into antibody-secreting cells that generate
autoantibodies against host tissues

Answer

Regulatory
T cells activate cytotoxic lymphocytes to eliminate infected host cells and
resolve inflammation

Answer

T
cells suppress immune activation by inhibiting inflammatory cytokine production
within affected tissues

Answer

Autoreactive
T cells recognise self-antigens and promote tissue damage through inflammatory
cytokine production and cytotoxic activity

Crowdly

Biopsies from inflamed tissues in patients with an autoimmune disorder reveal l...

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