Simple diffusion is too fast and would not allow us to control muscle and there are no glial cells at the NMJ for use of uptake mechanisms

Simple diffusion is constrained by the trough design of the NMJ and there are no glial cells at the NMJ for use of uptake mechanisms

Simple diffusion would also cause diffusion of the AChE and glial cells at the NMJ are of the wrong type for re-uptake mechanisms

Simple diffusion would also cause diffusion of the AChE and there are no glial cells at the NMJ for the use of re-uptake mechanisms

Simple diffusion is constrained by the trough design of the NMJ and glial cells at the NMJ do not produce enough AChE