POMC neurons co-express NPY and GABA and are activated by insulin and leptin, but inhibited by ghrelin

AgRP neurons co-express NPY and GABA, where NPY is a slow acting neuropeptide, whereas AgRP and GABA are fasting acting orexigens

AgRP neurons co-express NPY and GABA, where GABA is fast acting to cause inhibition of the POMC neurons

POMC neurons co-express NPY and GABA, respond to negative energy balance and their activity can be regulated by ghrelin, leptin and insulin