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A hospital microbiology lab identifies a strain of Acinetobacter baumannii wi...

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A hospital microbiology lab identifies a strain of

Acinetobacter

baumannii

with decreased sensitivity to a carbapenem antibiotic. Molecular

testing shows a truncating mutation in a gene encoding an outer‑membrane

channel protein that normally permits passive diffusion of certain antibiotics

into the bacterium.

Which resistance strategy does this mutation most directly

represent?

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