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The mechanisms to reduce a cell's ability to respond to high levels of a chemical are mainly
G protein coupled signalling mechanisms, Increased refractoriness and Decreased affinity
Pre-synaptic inhibition and Pre-synaptic facilitation
Activation of inactivation sites, Down regulation and Sequestration
Pre-synaptic inhibition and Post-synaptic inhibition
Activation of Desensitization sites, Increased refractoriness and Decreased affinity
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