The HEP-M2 cell lines carries a mutation in the acyl-CoA dehydrogenase subunit i...
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The HEP-M2 cell lines carries a mutation in the acyl-CoA dehydrogenase subunit interface domain (SID). SID mediates inter-subunit interactions and forms the internal core of the acyl-CoA dehydrogenase homotetramer. An excerpt of the amino acid sequence of the SID domain for normal healthy hepatocytes compared to HEP-M2 cells is shown below:
- Normal: -Leu-Val-Ala-Ala-Ile-
- HEP-M2: -Leu-Val-Gln-Ala-Ile-
Explain why the mutation in the HEP-M2 cell line disrupts the
assembly of the acyl-CoA dehydrogenase homotetramer. (2-3 sentences) (2 marks)
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