GWAS

are important in identifying monogenetic mutations that can lead to obesity and

aberrant metabolic function

FTO

over-expression in mice increases intake of highly caloric foods without an

associated change in energy expenditure, leading to increased fat mass

Increased

food intake without any observable changes in food preference, which leads to

weight gain

FTO over-expression in mice increases intake of

highly caloric foods and reduces energy expenditure via both physical activity

and ‘browning’ of white adipose tissue