A 12-year-old female is diagnosed with a rare neuromuscular disorder characterized by muscle weakness, lactic acidosis, and exercise intolerance. Her mother and maternal grandmother both have milder symptoms of the same condition.
Which of the following statements best explains the inheritance pattern and clinical variability observed in this family?

Question

A 12-year-old female is diagnosed with a rare neuromuscular disorder characterized by muscle weakness, lactic acidosis, and exercise intolerance. Her mother and maternal grandmother both have milder symptoms of the same condition.

Which of the following statements best explains the inheritance pattern and clinical variability observed in this family?

Answer

The variant is inherited from both parents, but only expressed in females due to genomic imprinting

Answer

The disorder follows mitochondrial inheritance, and variability in symptoms is due to heteroplasmy

Answer

The disorder is inherited in an autosomal dominant fashion with incomplete penetrance

Answer

The disorder is X-linked recessive with variable expressivity

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A 12-year-old female is diagnosed with a rare neuromuscular disorder characteri...

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