The B cell changes its antigen specificity so it can attack a different type of pathogen

The B cell undergoes apoptosis to ensure that only the original IgM antibodies remain in the blood

The B cell changes the constant region of the antibody heavy chain (e.g., from IgM to IgG) while keeping the same antigen specificity

The B cell switches from using a T cell-independent pathway to a T cell-dependent pathway

The B cell swaps its light chains for heavy chains to increase the binding affinity of the antibody