A 58 year old man is diagnosed with type 2 DM for 15 years, he visits the neurologist with diminished sensation in his hands and legs. Examination shows loss of pain sensation from distal parts of his upper and lower limbs.
Which is the most likely pathophysiological mechanism of his condition?

Question

A 58 year old man is diagnosed with type 2 DM for 15 years, he visits the neurologist with diminished sensation in his hands and legs. Examination shows loss of pain sensation from distal parts of his upper and lower limbs. 
 Which is the most likely pathophysiological mechanism of his condition?

Accepted Answer

glycation of his nerves’ basement membrane and loss of blood supply to his peripheral nerves

Answer

compression on his sensory nerves and block of sensory signals at the spinal cord

Answer

sensory cortex affection and loss of the ability to perceive pain impulses

Answer

inflammation causing a lesion in the lateral spinothalamic tract at the spinal cord

Answer

loss of receptors for pain sensation on the skin of both upper and lower limbs

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A 58 year old man is diagnosed with type 2 DM for 15 years, he visits the neurol...

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