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At the skeletal muscle motor end plate, the time between Ca++ influx and exocytosis is fast because
Vesicles can fuse rapidly to the terminal membrane.
Otherwise AChE would degrade the Ca++.
ACh can diffuse rapidly across the synaptic cleft.
Ca++ facilitates ACh entry into vesicles
Synaptic vesicles are pre-docked to take advantage of the brief period of Ca++ entry
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