Kabelo

started using methamphetamine after moving to an area with high drug

availability and poor community resources.

Charles

began using cannabis to cope with anxiety, which he attributes to a

neurotransmitter imbalance and a history of family addiction.

Zanele

developed substance dependence solely due to the reinforcing effects of

dopamine on the brain's reward circuitry.

Thandi

uses alcohol regularly after watching her parents drink socially and observing

media portrayals that normalise excessive drinking.