The type of response that is generated to a particular pathogen can be influenced by genetics, such that, in different individuals, it may skew towards a TH1 or TH2 response to the same pathogen. In humans that develop a strong TH2 response to the macrophage intracellular pathogen Mycobacterium leprae, the more destructive form, called Lepromatous leprosy, is associated with:
Loss of MHC expression in infected macrophages
0%
Increased M1 macrophage activity
0%
Increased M2 macrophage activity
✅
Inhibition of all macrophage effector mechanisms in infected, and local, macrophages
0%

Question

The type of response that is generated to a particular pathogen can be influenced by genetics, such that, in different individuals, it may skew towards a TH1 or TH2 response to the same pathogen. In humans that develop a strong TH2 response to the macrophage intracellular pathogen Mycobacterium leprae, the more destructive form, called Lepromatous leprosy, is associated with:

Loss of MHC expression in infected macrophages

0%

Increased M1 macrophage activity

0%

Increased M2 macrophage activity

✅

Inhibition of all macrophage effector mechanisms in infected, and local, macrophages

0%

Accepted Answer

Increased M2 macrophage activity

Answer

Loss of MHC expression in infected macrophages

Answer

Increased M1 macrophage activity

Answer

Inhibition of all macrophage effector mechanisms in infected, and local, macrophages

Crowdly

The type of response that is generated to a particular pathogen can be influence...

Want instant access to all verified answers on learning.monash.edu?