Individuals are born with a variable number of nephrons.
According to the Brenner Hypothesis, lower nephron endowment places greater
functional demands on individual nephrons, which may ultimately contribute to
hypertension and chronic kidney disease.

A researcher measures nephron number, single
nephron glomerular filtration rate (SNGFR), glomerular size, podocyte density,
and blood pressure in a population of adults. Which pattern of findings would
most strongly support the Brenner Hypothesis?

Question

Individuals are born with a variable number of nephrons.
According to the Brenner Hypothesis, lower nephron endowment places greater
functional demands on individual nephrons, which may ultimately contribute to
hypertension and chronic kidney disease.

A researcher measures nephron number, single
nephron glomerular filtration rate (SNGFR), glomerular size, podocyte density,
and blood pressure in a population of adults. Which pattern of findings would
most strongly support the Brenner Hypothesis?

Accepted Answer

Individuals
with lower nephron number have higher SNGFR in remaining nephrons, glomerular
hypertrophy with reduced podocyte density, and are likely to develop glomerulosclerosis
and higher blood pressure

Answer

Individuals
with lower nephron number have normal SNGFR, reduced podocyte density, but no
change in glomerulosclerosis or blood pressure

Answer

Individuals
with lower nephron number have proportionately reduced SNGFR, preserved
podocyte density, no glomerulosclerosis, and normal blood pressure

Answer

Individuals
with lower nephron number have higher SNGFR but maintain podocyte density and
show no increase in glomerulosclerosis or blood pressure

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Individuals are born with a variable number of nephrons. According to the Brenn...

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