The effects of β-adrenoceptor blockade on exercise-induced changes in the cardi...
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The effects of β-adrenoceptor blockade on exercise-induced changes in the cardiovascular and autonomic nervous system
In the graph below, data for atenolol and placebo are taken from the collated practical classes in 2022, while data for pindolol was obtained from a previous cohort of students.Figure 6: The effect of β-adrenoceptor antagonists on perceived exertion during exercise (fatigue) in healthy individuals over time. Placebo (vitamin B6, 10 mg), atenolol (50 mg) or pindolol (10 mg) were administered at 0 min. Data shown as mean ± s.e.m. * p<0.05 drug vs placebo (ANOVA); n = 41-73 per treatment.
In your practical class, you learned that β-adrenoceptor blockade increase fatigue during exercise. What is a possible explanation for the unchanged fatigue level observed for atenolol in this graph?
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