QInB=61

A 65-year-old man with chronic myeloid leukemia on imatinib develops severe muscle pain after starting simvastatin for hyperlipidemia. What is the most likely explanation for this adverse effect?

Question

QInB=61
 
   A 65-year-old man with chronic myeloid leukemia on imatinib develops severe muscle pain after starting simvastatin for hyperlipidemia. What is the most likely explanation for this adverse effect?

Answer

Imatinib and simvastatin compete for albumin binding

Answer

Imatinib inhibits CYP3A4, increasing simvastatin levels

Answer

Imatinib reduces simvastatin absorption

Answer

Simvastatin inhibits imatinib excretion

Answer

imvastatin induces imatinib metabolism

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QInB=61 A 65-year-old man with chronic myeloid leukemia on imatinib develop...

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