What specific role does the zinc
transporter ZIP1 play in normal prostate epithelium, and how is this pathway
altered in prostate cancer cells?

Question

Accepted Answer

ZIP1 imports zinc to inhibit aconitase
conversion of citrate, promoting citrate accumulation.

Answer

ZIP1
imports zinc to activate ATP citrate lyase directly, accelerating de novo
lipogenesis.

Answer

ZIP1 imports zinc to inhibit isocitrate dehydrogenase, forcing elevated lactate secretion.

Answer

ZIP1 exports zinc to deplete cytosolic citrate, accelerating aerobic TCA cycle activity.

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