A patient with RA and moderate disease activity is started on methotrexate. What is the optimal evidence-based dosing and route escalation strategy if the response is insufficient?

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Answer

Increase the oral dose to 25 mg/week, then switch to subcutaneous administration if still insufficient.

Answer

Increase the oral dose to 30 mg/week and add folic acid 5 mg daily.

Answer

Add a TNF-inhibitor after 4 weeks of methotrexate.

Answer

Switch to subcutaneous administration immediately for better bioavailability.

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Decrease the methotrexate dose and add leflunomide.

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A patient with RA and moderate disease activity is started on methotrexate. What...

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