Transduction for bitter and sweet tastants ultimately involves the movement of Na+ ions into the cell because of the actions of

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Endocytosis of Ca++ ions which then act on docked vesicles of Na+

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Endocytosis of Ca++ ions which then act on voltage-gated Na+ ion channels

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Endocytosis of Ca++ ions which then act on primed and docked vesicles of Na+

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Ca++ ions released from internal stores and acting on TRP ion channels that allow Na+ influx

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Exocytosis of Ca++ ions which then act on voltage-gated Ca++ ion channels

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