Explain how the

sequence variant identified in the patient leads to the mitochondrial

morphology observed in their fibroblasts. In your answer, describe the sequence

variant at the DNA level, its effect on the MFN2 protein, and the resulting

impact on mitochondrial fusion and mitochondrial network structure. Also

comment on how these cellular changes may contribute to the patient’s clinical

presentation. (4-5 sentences) (5 marks)