In humans, brown adipose tissue levels decline during early life as muscle develops the ability to shiver, however BAT is reinstated across puberty

In brown adipose tissue, adaptive thermogenesis is enhanced in the β-less mice that lack all three β-adrenergic receptors

In brown adipose tissue, activation of the SNS causes lipolysis and the mobilisation of triglycerides, which can activate UCP1 and cause thermogenesis

In skeletal muscle, adaptive thermogenesis occurs via futile calcium cycling and NOT mitochondrial uncoupling pathways