Lipotoxicity

increases the concentration of ceramides in myocytes, ceramides inhibit insulin

signalling by directly blocking the phosphorylation of IRS-1

Lipotoxicity

leads to increased levels of long-chain fatty acids, the ceramides and

diacylglycerols (DAGs) because of partial oxidation of fatty acids, which in

turn interfere with insulin signalling

Lipotoxicity

leads to increased production of short-chain fatty acids, the ceramides and

diacylglycerols (DAGs) because of complete oxidation of fatty acids, which in

turn interfere with insulin signalling

Lipotoxicity

increases the concentration of diacylglycerides (DAGs) in myocytes, DAGs

inhibit insulin signalling by directly blocking the phosphorylation of Akt