The most relevant side effect of COX2 selective inhibitors is increased risk of cardiovascular and cerebrovascular events (arterial thrombosis). Which of the following is the cause of this dangerous side effect?

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Inibition of prostacyclin (PGI2) syntesis by endothelial cells

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Inhibition of the production of leukotriene B4 (LTB4)

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Inhibition of tromboxane A2(TXA2) production by platelets

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Increased release of PGE2

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Inhibition of stomach acid secretion

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