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Accurate chromosome segregation during meiosis relies on the integrity of the m...

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Accurate chromosome segregation during meiosis relies on the

integrity of the meiotic spindle and the presence of cohesin proteins that hold

sister chromatids together. Age‑related deterioration of these

mechanisms is a major contributor to aneuploidy in human oocytes.

Which of the following changes is most likely to

cause chromosomal misalignment during meiosis?

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