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One of the reservoirs for Proteus vulgaris is the human intestinal tract.  ...

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One of the

reservoirs for

Proteus vulgaris is the human intestinal tract.  P. vulgaris

is known to be resistant

to tetracyclines; the following plasmid has been isolated from

P. vulgaris.

 

Image failed to load: plasmid

The human intestinal tract is also a common reservoir for 

Escherichia coli.  Your research team studies different strains of E. coli isolated from human faecal samples.  Most strains of E. coli are susceptible to tetracycline.  You have just demonstrated that E. coli strain 3022 (previously known to be susceptible to tetracycline), now uses the exact same mechanism for tetracycline resistance as P. vulgaris

Using the information presented in this scenario, what is the most likely

mechanism to explain how

E. coli

strain 3022 is now resistant to

tetracycline?  Give a brief explanation of the mechanism to support your response.

[5 marks]

[max. 100 words]

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