Which of
the following most accurately summarizes leptin's integrated role in regulating
appetite and reward according to experimental and fMRI evidence?

Question

Accepted Answer

Leptin signals positive energy balance by activating satiety-promoting POMC neurons and inhibiting hunger-driving AgRP neurons in the ARC, while also acting in the VTA to suppress dopamine neuronal firing and reduce the rewarding properties of food.

Answer

Leptin treatment in leptin-deficient individuals leads to increased BOLD activation in the Putamen and Nucleus Accumbens specifically when viewing images of palatable food.

Answer

Leptin acts
as a rapid feedforward signal during the cephalic phase, binding to receptors
on AgRP neurons to predict the caloric density of an upcoming meal.

Answer

Leptin primarily regulates energy balance by binding to GHSR on AgRP neurons, which triggers a negative reward prediction error when fat mass exceeds homeostatic boundaries.

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Which of the following most accurately summarizes leptin's integrated role in re...

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