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Q2f. The patient previously discontinued a Combined Oral Contraceptive (COC) due to nausea and breakthrough bleeding. The estrogenic component of most COCs is Ethinyl Estradiol (EE) or Mestranol (shown below). Why are these synthetic estrogens used in oral contraceptives instead of natural 17β-estradiol, and how do they differ chemically from one another? (2 marks)
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