The difference between pre-synaptic inhibition and pre-synaptic facilitation is that

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They modulate pre-synaptic terminal Ca ++  levels in opposite ways

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They modulate whether neurotransmitter is produced in the pre-synaptic terminal  or in the cell body

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They modulate in different ways the way in which neurotransmitter is packaged into vesicles

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They modulate in different ways the way in which neurotransmitter is produced in the pre-synaptic terminal

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They cause vesicles in the pre-synaptic terminal vesicles to fuse with the membrane in different ways

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