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During lead optimisation, all lead compounds were evaluated for carcinogenic ef...
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During lead optimisation, all lead compounds were evaluated for carcinogenic effects using the Ames test.
Table 3: Assessment of growth of his- salmonella in histidine free media in the absence or presence of liver extract.
Compound | his- salmonella colony growth | |
| -Liver extract | +Liver extract |
EL-01 | No growth | No growth |
EL-02 | ++ | No growth |
EL-03 | No growth | ++ |
EL-04 | ++ | ++ |
++ = colony growth
Based upon the data shown above in Table 3, which of the following compounds only has mutagenic potential in its active, non-metabolised form?
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