Placental development depends on adequate maternal blood
flow to sustain oxygen and nutrient delivery to the fetus. When placental
perfusion is impaired, local hypoxia can result and initiate cellular stress
responses, increasing oxidative stress.

Which mechanism best explains the contribution
of placental hypoxia to fetal growth restriction?

Question

Placental development depends on adequate maternal blood
flow to sustain oxygen and nutrient delivery to the fetus. When placental
perfusion is impaired, local hypoxia can result and initiate cellular stress
responses, increasing oxidative stress.

Which mechanism best explains the contribution
of placental hypoxia to fetal growth restriction?

Accepted Answer

Impaired
placental perfusion causes hypoxia that activates stress signalling pathways
and increases ROS production

Answer

Reduced
maternal oxygen levels explains placental hypoxia without any role for
placental blood flow or signalling mechanisms

Answer

Hypoxia
acts solely by producing ROS, which directly inhibit fetal cell division
without placental mediation

Answer

Excess
ROS arise independently and subsequently reduce placental oxygen delivery

Crowdly

Placental development depends on adequate maternal blood flow to sustain oxygen...

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