Brown

adipocytes maintain a stable identity derived from Myf5+ progenitors shared

with skeletal muscle, whereas beige adipocytes originate from Myf5– precursors

and exhibit high plasticity, capable of undergoing "browning" via

The "browning" of white adipose tissue is a permanent developmental shift triggered by β3-adrenergic antagonism, which allows Myf5+ progenitors to bypass mitochondrial uncoupling and maximize ATP synthesis during periods of high-fat feeding.

Beige

adipocytes are the primary constitutive thermogenic cells found in the

interscapular depots of infants, while brown adipocytes are inducible cells

recruited in adults via the transdifferentiation of Myf5– myocytes during

chronic cold exposure

Both brown and beige adipocytes originate from Myf5+ mesenchymal stem cells, but they differ in that BAT is constitutively thermogenic while beige cells require the ectopic expression of the Myf5 gene to maintain UCP1 activity.