Ghrelin increases food intake via activation glucose sensing within the lateral hypothalamus and thus triggering a hunger signal

Ghrelin acts direct at NPY/AGRP neurons to promote food intake via NPY action at the Y1 and Y2 receptors and AGRP antagonism at the MC4R

Ghrelin increases food intake by activating the

NPY/AGRP neuron and indirect inhibition of POMC neurons

Ghrelin increases food intake via direct inhibition of POMC neurons in the arcuate nucleus and therefore decreases the secretion of αMSH